Cancer-causing potential of bisphenols
Breast Cancer UK is pleased to have awarded Dr Michael Antoniou and Dr Robin Mesnage (from King’s College London) funding to evaluate the cancer-causing potential of bisphenol combinations in primary mammary epithelial cells. Previously, Dr Antoniou was awarded research grants to evaluate the endocrine disrupting properties of the herbicide glyphosate, and to investigate the endocrine disrupting effects of low dose EDC mixtures of herbicides and plasticisers (bisphenol compounds).
The study will assess the breast cancer-causing and growth stimulating properties of a mixture of bisphenol substitutes, using cultures of human breast epithelial cells, which can form 3-dimensional breast-like cellular structures known as “mammospheres” . These are more representative of breast architecture than standard breast cell culture systems, as they can reproduce features of malignant changes which can be observed microscopically and monitored using molecular biology methods.
Mixtures of endocrine disrupting chemicals can have potent biological effects at concentrations at which they are inactive when tested individually. Bisphenol mixtures at different concentrations will be tested for oestrogenic effects.
The study will help identify potential risks arising from ingestion of bisphenols in foodstuffs that can potentially lead to, or promote growth of, breast cancer.
The project will begin in April, and is expected to last two years. It will involve collaboration with Dr Elisabete Silva, from Brunel University, who will assist with development of the 3- dimensional breast cell culture system.
page last updated March 8, 2018