Dr Isabel Pires’s research focuses on characterising cellular signalling pathways associated to hypoxia and their exploitation for therapeutic benefit, with a particular emphasis on improving response to radiotherapy. Isabel did her PhD at the University of Manchester/CRUK Manchester Institute with Professor Caroline Dive. She then moved to the University of Oxford for a postdoc in Professor Ester Hammond’s group at the CRUK/MRC Institute for Radiation Oncology. There Isabel became interested in how hypoxic biology leads to alterations in cellular behaviour, such as increased genomic instability, resistance to therapy, and increased metastatic potential. She then moved to the University of Hull as a lecturer and then later a senior lecturer, where she continued her interest in hypoxic biology and radiobiology. In 2023 her group moved to the University of Manchester, where is continues her work on hypoxia biology.
