2 years ago
Q. Your current Breast Cancer UK funded research project is looking into the cancer-causing potential of bisphenols in breast tissue. For people who are not familiar with the scientific names used for chemicals, please can you tell us what are Bisphenols and how are they used?
A. Bisphenols are a family of substances that are used in the manufacture of certain types of plastics used to make packaging for food and drink, the most common being BPA. Bisphenols are collectively known as plasticisers.
Q. Why should we be concerned about them, and how are they linked to breast cancer?
A. Structurally bisphenols resemble the hormone oestrogen, which is found mainly in women and is needed for normal body function. As bisphenols are structurally similar to oestrogen, it has been found that they can mimic its effects; that is, bisphenols can behave like oestrogen and can affect the functioning of the body in a similar way to the natural hormone.
Importantly, many breast cancers are hormone dependent; that is, they need oestrogen in order to grow. Since bisphenols can behave like oestrogen, this means that they can also potentially stimulate the growth of hormone dependent breast cancers.
Q. Can you tell us what you hope to achieve with this research project?
A. Because of concerns about the safety of BPA, plastics manufacturers have begun to replace it with other bisphenols claiming that these substitutes are safer. We are trying to find out if this will, indeed, be the case. In previous BCUK-funded research it was shown that 6 BPA substitutes that are used in plastics manufacture and often found in our bodies can mimic the actions of oestrogen. Indeed, we found that 3 of the BPA substitutes were far more potent at simulating the effects of oestrogen than BPA itself.
The results called into question the claims that the BPA substitutes are safer as in principle they could be even more potent. Although research has highlighted the potential for bisphenols to stimulate the growth of a pre-existing hormone-dependent breast cancer, what is not clear is if this family of chemicals can give rise to the breast cancer in the first place. Our latest BCUK funded project will be testing to see if mixtures of bisphenols we have worked with before can disrupt the growth of normal breast cancer cells in a manner that would be indicative that they could progress to a cancer.
We are working in collaboration with Dr Elisabete Silva at Brunel University London. Dr Silva has already shown that BPA on its own can cause severe disruption to normal breast cancer cell growth, which could lead to a fully blown cancerous state. It is therefore possible that a low dose mixture of bisphenols will be even more capable of disrupting normal breast cancer cell growth with potentially devastating outcomes if this was to happen in people and especially women.
Q. Bisphenols are one of several chemicals which have been classed as hormone disrupting chemicals (sometimes referred to as HDCs or EDCs), for people new to this area of science please can you tell us what these are, and what effect they have on our health?
A. Hormones are natural substances in our bodies. The balanced functioning of hormone systems is vital to our health. HDCs disrupt the normal functioning of one or more hormones by either blocking their activity or mimicking (boosting) their effects.
Imbalances to hormone function caused by HDCs can lead to many serious health problems, both physical and behavioural in nature. HDCs begin to exert their effects at the time when the foetus is forming in the mother’s womb with problems spilling over into later life. Among the illnesses that can arise from HDCs are birth defects, neurological development problems, obesity, diabetes, hormone dependent cancers, autoimmune disease, infertility, heart disease and ADHD.
As hormones are essential for normal body function, we should not be surprised to find that anything that interferes with their activity can lead to a large array of serious diseases. As a result it estimated that illnesses that are either directly caused or aggravated by HDCs cost health services hundreds of billions of Euro in Europe (including the UK) and hundreds of billions of dollars in the USA each year!
Q. How do we encounter HDCs, and especially bisphenols, in our everyday lives?
A. The list of HDCs is huge, growing all the time and we encounter them on virtually a daily basis both at home and in the environment. Many types of chemicals (pesticides) used in agriculture have been found to be HDCs and so can be found in food. Within the home, flame retardants applied to furniture are also HDCs. There is evidence that some additives to cosmetics such as parabens and phthalates are also HDCs. Bisphenol plasticisers are used to make clear plastic bottles for water, soft and alcoholic drinks, and the plastic that lines food and drink cans and as a coating of thermal receipt papers.
Q. How do HDCs increase our risk of breast cancer?
A. HDCs increase the risk of breast cancer in two ways. First, they can contribute to breast cancer formation. Second, they can promote the growth of breast cancer, which has been caused by some other mechanism. HDCs exert these effects by changing the patterns of gene function from a healthy balanced state to an imbalanced state where normal cell growth is replaced with growth that is out of control.
Q. Should we be concerned about our daily exposure to HDCs?
A. Yes. The wide range of illnesses that can arise from long term, daily ingestion of HDCs can affect both sexes equally in similar and different ways.
Q. What would you recommend we do to reduce our exposure?
A. We can all reduce our daily exposure to HDCs in several ways. I list some of the easier lifestyle changes to reduce HDC exposure below.
30 March 2021
To celebrate Pesticide Action Week, Dr Robin Mesnage, a Research Associate at Kings College and member of Breast Cancer UK's Scientific Review Panel investigates the links between pesticides and breast...Read full story
10 March 2021
While 2020 brought us many unexpected challenges, it also brought exciting developments! Initial results from the research you helped fund have identified new techniques that will improve investigations of bisphenols...Read full story
1 February 2021
As part of our interview series, Meet the Scientists, we caught up with PhD student Freya Leif, who is at Leeds University working on a Breast Cancer UK funded research...Read full story
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